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A Commentary on Mitochondrial Dysfunction and Compromised DNA Repair in Neurodegeneration: The Emerging Role of FUS in ALS.
Neurosci Insights
December 2024
Department of Neurosurgery, Center for Neuroregeneration, Houston Methodist Research Institute, Houston, TX, USA.
Mitochondrial dysfunction plays a pivotal role in the progression of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Alzheimer's, and Parkinson's disease. Recent discoveries have highlighted the involvement of DNA damage and repair processes, particularly mitochondrial DNA (mtDNA) damage, in these conditions. This commentary reflects on our recent findings, demonstrating the RNA/DNA binding protein fused in sarcoma (FUS)'s crucial role in maintaining mtDNA integrity through interactions with mitochondrial DNA ligase IIIα (mtLig3).
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- Hip arthroscopy is a newer procedure compared to total hip arthroplasty, leading to increased research on hip-spine syndrome in young adults and how hip health affects spine health and vice versa.
- Patients with spine issues may experience worse outcomes and increased spinal symptoms post-hip arthroscopy, but some may benefit from improved back symptoms after the procedure.
- A thorough assessment of a patient's spinal condition and symptoms is crucial before surgery to determine the likelihood of success, with certain factors like prior spinal surgery influencing outcomes significantly.
Comment on Ohyama et al.: Does vacuum phenomenon at non-fused discs affect the postoperative course after transforaminal lumbar interbody fusion in patients showing a positive value of difference in lumbar lordosis?
J Orthop Sci
September 2024
Department of Orthopedics, Affiliated Hospital of Jining Medical University, Jining City, China. Electronic address:
AI-driven designed protein epigenomics.
Clin Res Oncol
January 2023
Institute for Stem Cell and Regenerative Medicine, University of Washington, School of Medicine, Seattle, WA 98109, USA.
The biological revolutions of computationally designed proteins, induced pluripotent stem cells (iPSCs), and the CRISPR-Cas9 system finally enables modifications that can spur deep understanding of spatial requirement of epigenetic information. This commentary describes the utility of a computationally designed protein, EED Binder (EB), when fused to dCas9 (EBdCas9) for identifying critical sites of PRC2 dependent histone H3K27me3 marks in the chromatin. By using EBdCas9 and gRNA, PRC2 function can be inhibited at specific loci, resulting in precise reduction of EZH2 and H3K27me3 marks, and in some (but not all) locations, activation of the gene and functional outcomes (such as regulation of cell cycle or trophoblast transdifferentiation).
View Article and Find Full Text PDFDo electronic cigarette devices/vapes impact the colour of dental ceramics?
Evid Based Dent
December 2023
Dundee Dental Hospital and Research School, Dundee, Scotland, UK.
Design: In vitro primary research study.
Case Selection And Method: Five frequently used restorative dental ceramic materials (pressable ceramics (PEmax), pressed and layered ceramics (LEmax), layered zirconia (LZr), monolithic zirconia (MZr) and porcelain fused to metal (PFM)) were selected and manufactured in shade A1. Samples of each material were prepared in discs and kept in water at 37°C for 24 hours then aged via thermocycling.
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