AI Article Synopsis
- The study aimed to analyze differences in treatment practices and outcomes for newborns with hypoxic-ischemic encephalopathy (HIE) receiving therapeutic hypothermia in Canadian neonatal intensive care units (NICUs) from 2010 to 2020.
- A total of 3,261 neonates were treated, with 11% dying before discharge and 37% showing MRI-detected brain injury, highlighting significant variations in mortality and brain injury rates across different NICUs.
- The findings point to notable discrepancies in treatment methods (like the use of inotropes and blood products), suggesting a need for standardization in care practices for HIE in neonates across Canada.*
Article Abstract
Objective: To characterize variations in practices and outcomes for neonates with hypoxic-ischemic encephalopathy (HIE) treated with therapeutic hypothermia (TH) across Canadian tertiary Neonatal Intensive Care Units (NICUs).
Study Design: Retrospective study of neonates admitted for HIE and treated with TH in 24 tertiary NICUs from the Canadian Neonatal Network, 2010-2020. The two primary outcomes of mortality before discharge and MRI-detected brain injury were compared across NICUs using adjusted standardized ratios (SR) with 95% CI.
Results: Of the 3261 neonates that received TH, 367 (11%) died and 1033 (37%) of the 2822 with MRI results had brain injury. Overall, rates varied significantly across NICUs for mortality (range 5-17%) and brain injury (range 28-51%). Significant variations in use of inotropes, inhaled nitric oxide, blood products, and feeding during TH were identified (p values < 0.01).
Conclusion: Significant variations exist in practices and outcomes of HIE neonates treated with hypothermia across Canada.
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| http://dx.doi.org/10.1038/s41372-022-01412-7 | DOI Listing |
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