AI Article Synopsis
- - The study analyzes the characteristics of central nervous system (CNS) tumors in children diagnosed at Beijing Tiantan Hospital from 2015 to 2019, focusing on factors such as age, gender preferences, tumor locations, and histological grades based on WHO classification.
- - Out of 3180 diagnosed cases, 96.4% were intracranial tumors, with a majority being low-grade, and the most common tumors identified included craniopharyngioma, medulloblastoma, and pilocytic astrocytoma.
- - This extensive data is significant as it fills a gap in national statistics on childhood brain tumors in China, offering a foundation for future clinical research in the field.
Article Abstract
Background: To describe the epidemiological characteristics of central nervous system (CNS) tumors in children, based on the neurosurgery department of Beijing Tiantan Hospital.
Methods: From January 2015 to December 2019, 3180 children were histopathologically diagnosed with CNS tumors based on the 2016 World Health Organization (WHO) classification of tumors. Patients were 0 to 15 years old. We analyzed age-related gender preferences, tumor locations, and the histological grades of the tumors. In addition, the epidemiological characteristics of the five most common intracranial tumors were compared to the previous studies.
Results: In this study, intracranial and spinal tumors account for 96.4% (3066) and 3.6% (114) of all tumors, with a preponderance of supratentorial tumors (57.9%). Among all pediatric patients, low-grade tumors comprise 67.1% (2 135). The integral gender ratio of males to females is 1.47: 1 and the average age of patients is 7.59 years old. The five most common intracranial tumors are craniopharyngioma (15.4%), medulloblastoma (14.3%), pilocytic astrocytoma (11.8%), diffuse astrocytoma (9.8%), and anaplastic ependymoma (4.8%).
Conclusions: Due to the lack of national data on childhood brain tumors, we used a large nationally representative population sample based on the largest pediatric neurosurgery center in China. We analyzed the data of the past 5 years, reflecting the incidence of CNS tumors in Chinese children to a certain extent, and laying a data foundation for subsequent clinical studies.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9096059 | PMC |
| http://dx.doi.org/10.1186/s41016-022-00279-z | DOI Listing |
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