Backgrounds: Evaluating the growth performance of pigs in real-time is laborious and expensive, thus mathematical models based on easily accessible variables are developed. Multiple regression (MR) is the most widely used tool to build prediction models in swine nutrition, while the artificial neural networks (ANN) model is reported to be more accurate than MR model in prediction performance. Therefore, the potential of ANN models in predicting the growth performance of pigs was evaluated and compared with MR models in this study.
Results: Body weight (BW), net energy (NE) intake, standardized ileal digestible lysine (SID Lys) intake, and their quadratic terms were selected as input variables to predict ADG and F/G among 10 candidate variables. In the training phase, MR models showed high accuracy in both ADG and F/G prediction (R = 0.929, R = 0.886) while ANN models with 4, 6 neurons and radial basis activation function yielded the best performance in ADG and F/G prediction (R = 0.964, R = 0.932). In the testing phase, these ANN models showed better accuracy in ADG prediction (CCC: 0.976 vs. 0.861, R: 0.951 vs. 0.584), and F/G prediction (CCC: 0.952 vs. 0.900, R: 0.905 vs. 0.821) compared with the MR models. Meanwhile, the "over-fitting" occurred in MR models but not in ANN models. On validation data from the animal trial, ANN models exhibited superiority over MR models in both ADG and F/G prediction (P < 0.01). Moreover, the growth stages have a significant effect on the prediction accuracy of the models.
Conclusion: Body weight, NE intake and SID Lys intake can be used as input variables to predict the growth performance of growing-finishing pigs, with trained ANN models are more flexible and accurate than MR models. Therefore, it is promising to use ANN models in related swine nutrition studies in the future.
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http://dx.doi.org/10.1186/s40104-022-00707-1 | DOI Listing |
Cardiol Ther
January 2025
Advocate Aurora Research Institute, Advocate Health, 945 N 12th St, Milwaukee, WI, 53233, USA.
Introduction: Oral anticoagulants (OAC) reduce the risk of stroke among patients with atrial fibrillation (AF). However, adherence remains suboptimal. We focused on primary nonadherence to OAC and its associations with patient characteristics-specifically social determinants of health collected in electronic health records (EHR).
View Article and Find Full Text PDFAnn Surg Oncol
January 2025
Breast Surgery Section, Division of GI and Oncologic Surgery, Massachusetts General Hospital, Boston, MA, USA.
Background: Nipple-sparing mastectomy (NSM) is infrequently performed in older women, at least in part owing to concerns regarding age-related complications. We describe postoperative outcomes of NSM in older women and risk factors for complications, with the goal of informing patient selection and decision-making.
Patients And Methods: Cases of NSM with immediate implant-based reconstruction were identified from an institutional database (2009-2019).
Alzheimers Dement
December 2024
University of Michigan, Ann Arbor, MI, USA.
Background: Alzheimer's disease (AD) is the leading cause of dementia worldwide. The recent announcement that lecanemab, a monoclonal antibody targeting amyloid-b, can slow down cognitive decline in AD is a great step forward in the battle against the disease. However, the modest success achieved in the clinical trial speak to the need for developing additional pharmaceutical approaches to target other key features of AD.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of Michigan, Ann Arbor, MI, USA.
Background: Inhibitory interneurons normally regulate neural networks underlying memory and cognition, but are disrupted in Alzheimer's disease. Proper interneuron activity reduces amyloid-beta, whereas hyperexcitability elevates amyloid levels. Still, the underlying pathologic processes mediating interneuron dysfunction remain unknown.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of Michigan Medical School, Ann Arbor, MI, USA.
Background: The transfer of mitochondrial DNA into the nuclear genomes of eukaryotes (Numts) has been linked to lifespan in non-human species and recently demonstrated to occur in rare instances from one human generation to the next.
Method: Here we investigated numtogenesis dynamics in humans in two ways. First, we quantified Numts in 1,187 post-mortem brain and blood samples from different individuals.
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