AI Article Synopsis
- Researchers have developed a comprehensive human reference atlas featuring nearly 500,000 cells from 24 different tissues to enhance our understanding of cell biology and organ physiology.
- This atlas allows for the detailed characterization of over 400 cell types, revealing how they are distributed across different tissues and how gene expression varies specifically within those tissues.
- By utilizing tissues from the same donor, the study reveals insights into the distribution of T cells, mutation rates in B cells, and unique RNA splicing events while analyzing shared cell types across various organs.
Article Abstract
Molecular characterization of cell types using single-cell transcriptome sequencing is revolutionizing cell biology and enabling new insights into the physiology of human organs. We created a human reference atlas comprising nearly 500,000 cells from 24 different tissues and organs, many from the same donor. This atlas enabled molecular characterization of more than 400 cell types, their distribution across tissues, and tissue-specific variation in gene expression. Using multiple tissues from a single donor enabled identification of the clonal distribution of T cells between tissues, identification of the tissue-specific mutation rate in B cells, and analysis of the cell cycle state and proliferative potential of shared cell types across tissues. Cell type-specific RNA splicing was discovered and analyzed across tissues within an individual.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9812260 | PMC |
| http://dx.doi.org/10.1126/science.abl4896 | DOI Listing |
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