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| http://dx.doi.org/10.1161/CIRCRESAHA.122.321142 | DOI Listing |
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Lnc-ing RNA to intestinal homeostasis and inflammation.
Trends Immunol
February 2024
Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:
Long noncoding RNAs (lncRNAs) play important roles in numerous biological processes, including the immune system. Initial research in this area focused on cell-based studies, but recent advances underscore the profound significance of lncRNAs at the organismal level, providing invaluable insights into their roles in inflammatory diseases. In this rapidly evolving field, lncRNAs have been described with pivotal roles in the intestinal tract where they regulate intestinal homeostasis and inflammation by influencing processes such as immune cell development, inflammatory signaling pathways, epithelial barrier function, and cellular metabolism.
View Article and Find Full Text PDF'Lnc-ing' T cells to the aging liver.
Nat Aging
July 2023
Cardiovascular Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Lnc-ing epicardium-derived cells to cardiac remodelling: lncRNA-TARID as a novel antifibrotic option.
Eur Heart J
May 2023
Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA.
Long Non-coding RNAs, Lnc RNA Metabolism to Cancer Biology.
Subcell Biochem
November 2022
RNP Biology Laboratory, Department of Biological Sciences, Indian Institute of Science Education and Research (IISER)-Berhampur, Transit Campus, Govt ITI Building, Engineering School Junction, Berhampur, Ganjam, Odisha, India.
The eukaryotic genome is represented by a vast proportion of non-coding regions, which in recent years have been attributed to have important functional roles in gene regulation through a myriad of processes, ranging from proper localization, correct folding and, most importantly, spatial and temporally regulated expression of genes. One of the major contributing factors in these processes is ribonucleic acid (RNA) metabolism, which comprises the RNA-nucleoprotein (RNP) complexes that interact with and instruct the genome to function. Long non-coding RNAs are an integral component of several RNPs, and herein we provide an overview of the understanding of the long non-coding RNAs, their characteristics, their function and their balancing act as dual modulators in cancer manifestation and progression.
View Article and Find Full Text PDFLong Noncoding RNAs That Function in Nutrition: Lnc-ing Nutritional Cues to Metabolic Pathways.
Annu Rev Nutr
August 2022
Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; email:
Article Synopsis
- Long noncoding RNAs (lncRNAs) are influenced by environmental changes and are important in managing health and diseases through regulating gene expression.
- Research highlights the role of lncRNAs in metabolic responses to different dietary conditions like fasting and high-fat diets specifically in liver, adipose, and muscle tissue.
- Understanding how lncRNAs react to nutritional changes is essential for comprehending the biological effects of diet on metabolism and may also illuminate sex differences in metabolic diseases.
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