AI Article Synopsis
- - Chemotherapy is a key method for treating cancer, but its effectiveness can be limited by issues like multidrug resistance and unpredictable drug release.
- - Researchers have developed a microRNA-responsive nanomedicine that targets cancer cells by using microRNA-21 as a trigger to enhance treatment through both chemotherapy and gene silencing.
- - This innovative nanomedicine, consisting of a gold nanoparticle core and a DNA layer, effectively controls drug release and reduces resistance, leading to better cancer cell killing and advancing the field of DNA-based cancer treatment.
Article Abstract
Chemotherapy is a prime tool for cancer clinical therapy. The effectiveness has been improved considerably with the assistance of nanotechnology. However, it still meets the challenge of unsatisfied therapeutic effects caused by multidrug resistance and uncontrollable drug release. For further enhancement of the treatment performance, we develop a kind of microRNA-responsive nanomedicine that uses the biomarker microRNA-21 as a trigger of cascaded killing effects on cancer cells, including chemotherapy and gene silencing. The nanomedicine consists of a gold nanoparticle core and a DNA layer. Strand migrations within the layer can accurately control the events of anticancer drug doxorubicin release and multidrug-resistant-associated protein 1 downregulation, yielding an alleviation of multidrug resistance and enhanced killing on cancer cells. This work demonstrates a microRNA-responsive nanomedicine in combination with chemotherapy and gene silencing, which paves the way to the advancement of DNA-based nanomedicine for cancer theranostics.
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| http://dx.doi.org/10.1021/acsmacrolett.1c00136 | DOI Listing |
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