Purpose: To evaluate the impact of cranial stereotactic radiotherapy (SRT) on overall survival (OS) of melanoma brain metastases (MBM) patients treated with combined nivolumab and ipilimumab (CNI) in a contemporary and real-world setting.
Methods/patients: The study was performed by using TriNetX, a global health network dataset of electronic medical records from patients in 49 healthcare organizations. We queried for patients with specific terms between January 2016 and December 2020 and run a propensity score matching (PSM) analysis. OS was estimated by Kaplan-Meier and log-rank test was applied.
Results: After initial query and PSM, 114 patients were selected in each cohort. Median OS was 327 days in CNI and not reached in the CNI + SRT cohort, with OS probability of 54.4 and 40.9%, respectively (log-rank P = .0057). CNI + SRT was associated with significantly decreased mortality (HR, 0.57; 95% CI 0.377-0.853; proportionality P = .0034).
Conclusions: This real-world analysis showed that CNI + SRT led to an improvement in OS compared to CNI.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s12094-022-02838-3 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Impact of Social Vulnerability, Race, and Urbanicity on Surgical Timing for Patients With Craniosynostosis.
Cleft Palate Craniofac J
December 2024
Division of Plastic and Reconstructive Surgery, University of Mississippi Medical Center, Jackson, USA.
Prior studies have linked the timing of craniosynostosis surgeries to several postoperative outcomes. However, less is known regarding the influence of sociodemographic factors on surgical timing for this population. This study investigates the influence of social vulnerability index (SVI), race, and urbanicity on the timing of craniosynostosis surgery.
View Article and Find Full Text PDFCorrelation Analysis Between Cortical Structural Features and Acoustic Features in Patients With Parkinson's Disease.
J Voice
December 2024
Neurology Department II, Fuyang People's Hospital, Fuyang, China. Electronic address:
Purpose: Parkinson disease (PD) is a progressive neurodegenerative disease. The aim of this study is to investigate the association between acoustic and cortical brain features in Parkinson's disease patients.
Methods: We recruited 19 (eight females, 11 males) Parkinson's disease patients and 19 (eight females, 11 males) healthy subjects to participate in the experiment.
[Analysis of root development of maxillary inverted impacted central incisor before and after orthodontic traction by CBCT].
Shanghai Kou Qiang Yi Xue
October 2024
Hefei Stomatological Hospital, Anhui Medical University, School of Stomatology. Hefei 230601, Anhui Province, China. E-mail:
Purpose: To investigate the changes of root development before and after orthodontic traction of maxillary inverted impacted central incisors using CBCT and Mimics software.
Methods: Ten patients, who had a maxillary inverted impacted central incisor, were treated using a modified movable retractor combined with surgical eruption. Cone-beam computed tomography(CBCT) was taken before and after treatment.
[Effect of retrograde dissection of the facial nerve along the mandibular margin on postoperative quality of life in patients with benign superficial parotid tumors].
Shanghai Kou Qiang Yi Xue
October 2024
Department of Stomatology, Qingdao Central Hospital, University of Health and Rehabilitation Sciences(Qingdao Central Hospital). Qingdao 266042, Shandong Province, China. E-mail:
Purpose: To assess the impact of retrograde dissection of the facial nerve along the mandibular margin on the postoperative quality of life in patients with benign superficial parotid tumors.
Methods: One hundred and sixteen patients who underwent surgical treatment for benign superficial parotid tumors at Qingdao Central Hospital from January 2020 to January 2023 were involved. The patients were randomly allocated into two groups, with 58 patients in each group using the touch ball method.
Prediction of the success of orthodontic treatment of impacted maxillary canines using panoramic radiography parameters: a retrospective cross-sectional study.
BMC Oral Health
December 2024
Faculty of Dentistry, Department of Orthodontics, Ondokuz Mayıs University, Atakum, Samsun, 55139, Turkey.
Background: This retrospective study aimed to investigate the relationships between the radiographic features of impacted maxillary canines (IMCs) and traction duration and the factors affecting treatment success.
Methods: Pre-treatment panoramic radiographs and patient records of 121 consecutive patients with IMCs were analyzed. The measurements included the angle of the IMC with the midline (α-angle), the horizontal position of the IMC relative to the adjacent teeth (S-Sector), the distance from the IMC to the occlusal plane (d-distance), the apex position of the IMC (A), and the vertical height of the IMC relative to the adjacent lateral tooth (V).
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!