Multicomponent synthesis of biologically relevant -benzyl dithiocarbamates from -quinone methides, amines, and carbon disulfide are described under catalyst and additive-free conditions. The reactions proceeded at room temperature in a short span of time with excellent yields. One of the synthesized compounds, showed considerable acetylcholinesterase (AChE) inhibitory (51.70 + 5.63% at 20 μm) and antioxidant (63.52 ± 1.15 at 20 μm) activities.
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| http://dx.doi.org/10.1021/acs.joc.2c00423 | DOI Listing |
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