AI Article Synopsis
- This study explores how the Cr-CEST MRI technique can assess damage in mouse testes caused by the chemotherapy drug cisplatin.
- The research involved injecting cisplatin into mice and comparing MRI results to a control group, revealing significantly reduced Cr-CEST effects in the treated group.
- Findings indicate a strong correlation between the Cr-CEST effects and tissue damage, suggesting Cr-CEST MRI is a valuable tool for evaluating testicular damage from cisplatin.
Article Abstract
Purpose: This study aimed to investigate the ability of creatine-chemical exchange saturation transfer (Cr-CEST) technique assessed through 7-T MRI to evaluate cisplatin-induced testicular damage.
Methods: We used 8-10 weeks C57BL/6 mice (n = 10) that were divided into a control group (n = 5) and a cisplatin-treated group (n = 5). The cisplatin group received cisplatin at a dose of 15 mg/kg, via intraperitoneal injection, while the control group received saline. MR images of mouse testes were acquired under anesthesia 18 days after the injection using a horizontal 7-T scanner. The pulse sequence consisted of rapid acquisition with a relaxation enhancement (RARE) with magnetization transfer. The Z-spectra were collected using a 2000-ms saturation pulse at a B amplitude of 1.2 μT, with frequencies varying from -4.8 to +4.8 parts per million (ppm). Maps of magnetization transfer ratio with asymmetric analysis (MTR) were reconstructed at a Cr metabolite concentration of 1.8 ppm.
Results: The Cr-CEST effect was significantly reduced in the cisplatin-treated group compared to the control group (MTR of control mice vs. cisplatin-treated mice: 6.9 [6-7.5] vs. 5.2 [4-5.5], P = 0.008). Correlation analysis revealed a strong correlation between the Cr-CEST effect and the pathological score (ρ = 0.93, P < 0.001).
Conclusion: Cr-CEST MRI can be useful for the evaluation of cisplatin-induced testicular damage in mice.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449556 | PMC |
| http://dx.doi.org/10.2463/mrms.mp.2021-0125 | DOI Listing |
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