Severity: Warning
Message: fopen(/var/lib/php/sessions/ci_sessionluv967hv9srllt18d5ejg0h4gmnhavq8): Failed to open stream: No space left on device
Filename: drivers/Session_files_driver.php
Line Number: 177
Backtrace:
File: /var/www/html/index.php
Line: 316
Function: require_once
Severity: Warning
Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)
Filename: Session/Session.php
Line Number: 137
Backtrace:
File: /var/www/html/index.php
Line: 316
Function: require_once
Severity: Warning
Message: file_get_contents(https://...@pubfacts.com&api_key=b8daa3ad693db53b1410957c26c9a51b4908&a=1): Failed to open stream: Network is unreachable
Filename: helpers/my_audit_helper.php
Line Number: 197
Backtrace:
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 197
Function: file_get_contents
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 271
Function: simplexml_load_file_from_url
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 1057
Function: getPubMedXML
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3175
Function: GetPubMedArticleOutput_2016
File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global
File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword
File: /var/www/html/index.php
Line: 316
Function: require_once
Cancer is one of the major causes of death and a significant obstacle to increasing life expectancy worldwide. Chemotherapy remains the first-line adjuvant therapeutic option for all stages of cancer, and it can effectively improve patients' prognosis in the short term. However, its long-term effect on extending patient survival is limited due to the emergence of drug resistance. The mechanisms involved in drug resistance are complicated and still not fully understood. Forkhead box class O3a (FOXO3a) belongs to the FOXO subfamily of forkhead transcription factors. It plays a crucial role in many aspects of cancer progression and drug resistance. Recent studies have shown that FOXO3a dysregulation contributes to drug resistance development through various mechanisms, including modulating oncogenic signaling pathways, evading apoptosis, promoting excessive drug efflux, inducing autophagy, facilitating epithelial to mesenchymal transition, enhancing DNA damage repair, and altering the characteristics of cancer stem cells. FOXO3a also exhibits great potential as a diagnostic and prognostic biomarker candidate and therapeutic target for cancer patients. In this review, we summarize recent findings on the roles and mechanisms of FOXO3a in cancer drug resistance and highlight its clinical implications as a biomarker and a therapeutic target in cancer treatment.
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http://dx.doi.org/10.1016/j.canlet.2022.215724 | DOI Listing |
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