Virulence triggered allergies: Pseudomonas gets the Las laugh.

Immunity

Molecular and Systems Physiology Lab, Gene Expression Lab, Nomis Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biology Studies, 10010 N. Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address:

Published: May 2022

AI Article Synopsis

  • The link between infectious diseases and allergies is still not well understood.
  • Agaronyan et al. (2022) research reveals that the bacteria Pseudomonas aeruginosa can alter the immune system, leading to an increase in type 2 immune responses.
  • This immune shift may change how the body reacts to harmless substances, triggering allergic reactions.

Article Abstract

The mechanisms of how infectious diseases contribute to allergy remain unanswered. In this issue of Immunity, Agaronyan et al. (2022) show that Pseudomonas aeruginosa drives immune deviation through induction of type 2 immune responses, resulting in niche remodeling that incites allergic responses to innocuous antigens.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.immuni.2022.04.011DOI Listing

Publication Analysis

Top Keywords

virulence triggered
4
triggered allergies
4
allergies pseudomonas
4
pseudomonas las
4
las laugh
4
laugh mechanisms
4
mechanisms infectious
4
infectious diseases
4
diseases contribute
4
contribute allergy
4

Similar Publications

Immunological findings of West Caucasian bat virus in an accidental host.

J Virol

January 2025

Laboratory for Emerging Viral Zoonoses, WOAH Reference Laboratory for Rabies, FAO and National Reference Centre for Rabies, Department for Research and Innovation, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Italy.

Unlabelled: The genus includes seventeen viral species able to cause rabies, an acute and almost invariably fatal encephalomyelitis of mammals. Rabies virus (RABV), which represents the type species of the genus, is a multi-host pathogen that over the years has undergone multiple events of host-switching, thus occupying several geographical and ecological niches. In contrast, non-RABV lyssaviruses are mainly confined within a single natural host with rare spillover events.

View Article and Find Full Text PDF

Unlabelled: Avian leukosis virus subgroup J (ALV-J) poses a significant threat to the poultry industry; yet, our understanding of its replication and pathogenic mechanisms is limited. The Ten-Eleven Translocation 2 (TET2) is an indispensable regulatory factor in active DNA demethylation and immune response regulation. This study reports a significant and time-dependent decrease in TET2 levels following ALV-J infection and shows that the reduction of TET2 protein is mediated by the autophagy pathway.

View Article and Find Full Text PDF

Immune responses to avian influenza viruses in chickens.

Virology

January 2025

Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1, Canada. Electronic address:

Chickens are a key species in both the manifestation of avian influenza and the potential for zoonotic transmission. Avian influenza virus (AIV) infection in chickens can range from asymptomatic or mild disease with low pathogenic AIVs (LPAIVs) to systemic fatal disease with high pathogenic AIVs (HPAIVs). During AIV infection in chickens, Toll-like receptor 7 and melanoma differentiation-associated gene 5 are upregulated to detect the single-stranded ribonucleic acid genomes of AIV, triggering a signaling cascade that produces interferons (IFNs) and pro-inflammatory cytokines.

View Article and Find Full Text PDF

In the coevolution of cotton and pathogenic fungi, resistant cotton varieties lead to an escalation in the virulence of Verticillium dahliae.

Ecotoxicol Environ Saf

January 2025

State Key Laboratory of Cotton Bio-breeding and Integrated Utilization, Institute of Cotton Research of Chinese Academy of Agricultural Sciences, Anyang 455000, China; Western Agricultural Research Center of Chinese Academy of Agricultural Sciences, Changji 831100, China. Electronic address:

Verticillium dahliae is highly prone to pathogenic differentiation and influenced by host cotton's resistance. To better understand the mechanisms of this phenomenon, we applied the host selective pressures of resistant and susceptible cotton varieties on V. dahliae strain Vd076 within an artificial cotton Verticillium wilt nursery and greenhouse.

View Article and Find Full Text PDF

Extracellular vesicles in ZIKV infection: Carriers and facilitators of viral pathogenesis?

Sci Prog

January 2025

Virology Group, Vice-Chancellor of Research, Universidad El Bosque, Bogotá, Colombia.

Zika virus (ZIKV) is a flavivirus of significant epidemiological importance, utilizing various transmission strategies and infecting "immune privileged tissues" during both the pre- and postnatal periods. One such transmission method may involve extracellular vesicles (EVs). EVs can travel long distances without degrading, carrying complex messages that trigger different responses in recipient cells.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!