In this issue of Immunity,Gideon et al. (2022) couple sophisticated single-cell analyses with detailed in vivo measurements of Mycobacterium tuberculosis granulomas to define the cellular and transcriptional properties of a successful host immune response during tuberculosis.
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| http://dx.doi.org/10.1016/j.immuni.2022.04.009 | DOI Listing |
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Decoding differentially expressed genes to identify potential immunity associated biomarkers in Tuberculosis: An integrative bioinformatics approach.
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Tuberculosis (TB) poses a significant threat to the Indian population, with India accounting for 20 % of the global TB cases. The current study aims to identify molecular biomarkers for better diagnostics by comparing the transcriptome signatures of healthy individuals against TB-affected individuals. Next-generation sequencing (NGS) tools were used to identify critical differentially expressed genes (DEGs).
View Article and Find Full Text PDFRepurposing a Fully Reducing Polyketide Synthase toward 2-Methyl Guerbet-like Lipids.
ACS Catal
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School of Chemistry, The University of Edinburgh, Edinburgh EH9 3FJ, U.K.
In nature, thousands of diverse and bioactive polyketides are assembled by a family of multifunctional, "assembly line" enzyme complexes called polyketide synthases (PKS). Since the late 20th century, there have been several attempts to decode, rearrange, and "reprogram" the PKS assembly line to generate valuable materials such as biofuels and platform chemicals. Here, the first module from () PKS12, an unorthodox, "modularly iterative" PKS, was modified and repurposed toward the formation of 2-methyl Guerbet lipids, which have wide applications in industry.
View Article and Find Full Text PDFCurrent treatments for tuberculosis primarily target () infections, often neglecting the emerging issue of latent tuberculosis infection (LTBI) which are characterized by reduced susceptibility to antibiotics. The bacterium undergoes multiple adaptations during dormancy within host granulomas, leading to the development of antibiotic-tolerant strains. The mycobacterial membrane plays a crucial role in drug permeability, and this study aims to characterize membrane lipid deviations during dormancy through extensive lipidomic analysis of bacteria cultivated in distinct media and growth stages.
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View Article and Find Full Text PDFDecoding the hidden realm: Molecular pioneering unravelling osteoarticular tuberculosis diagnosis.
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Article Synopsis
- Osteoarticular tuberculosis (TB) affects the bones and joints and is a rare type of TB that makes up about 1-3% of all cases.
- Diagnosing it quickly is really important, but traditional methods for testing have some problems, like taking too long and not always being accurate.
- New tests that look at the DNA of the bacteria causing TB may help diagnose it faster and more accurately, but more studies are needed to figure out how well these tests work and to find ways to improve them.
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