This review article surveys literature methods for the synthesis of six-membered cyclic carbonates using various substrates in the presence of CO with special emphasis on the mechanistic aspects of the reactions. We have classified these reactions based on the type of starting material.
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http://dx.doi.org/10.1039/c8ra01280f | DOI Listing |
Nanotechnology
December 2024
Chemistry, American University, 4400 Massachusetts Ave NW, Washington, Washington, District of Columbia, 20016-8002, UNITED STATES.
A phenol contains a six-membered, conjugated, aromatic ring that is bound to a hydroxyl group. These molecules are important in biomedical studies, aromatic food preparation, and petroleum engineering. Traditionally, phenols have been measured with several analytical techniques such as UV-VIS spectroscopy, fluorescence, liquid chromatography, and mass spectrometry.
View Article and Find Full Text PDFBiomacromolecules
December 2024
Chair of Macromolecular Chemistry, Julius-Maximilians-Universität Würzburg, Röntgenring 11, 97070 Würzburg, Germany.
Postpolymerization modifications are valuable techniques for creating functional polymers that are challenging to synthesize directly. This study presents aliphatic polycarbonates with pendant thiol-reactive groups for disulfide formation with mercaptans. The reductive responsive nature of this reaction allows for reversible postpolymerization modifications on biodegradable scaffolds.
View Article and Find Full Text PDFJ Org Chem
December 2024
College of Pharmacy & Graduate School of Pharmaceutical Sciences, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-Gu, Seoul 03760, Republic of Korea.
The concise and efficient total synthesis of (±)-tetraponerine-2 () and (±)-tetraponerine-4 () was achieved in 9% and 14% overall yield, respectively. The key step included the diastereoselective gold(I)-catalyzed intramolecular dehydrative amination of an allylic alcohol-tethered sulfamide to produce the 1,3-diamine moiety. The resulting olefinic side chain was then elaborated by cross-metathesis and cyclized to a five-membered pyrrolidine or a six-membered piperidine ring by intramolecular Mitsunobu -alkylation.
View Article and Find Full Text PDFJ Phys Chem A
December 2024
School of Chemical Engineering, University of Science and Technology Liaoning, Qianshan Road 185, Anshan 114051, Liaoning, China.
Angew Chem Int Ed Engl
November 2024
Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea.
The synthesis of chiral 1,1-diaryl compounds, particularly those containing a pyridine moiety, is of significant interest due to their pharmaceutical applications. Here, we report the development of a copper-catalyzed enantioselective 1,4-hydropyridylation of conjugated dienes. Utilizing 2-fluoropyridine as the electrophile, CuOAc, and the chiral ligand Tol-BINAP, we optimized reaction conditions to achieve the desired chiral 1,1-diaryl products containing both a pyridine and a cis-crotyl group.
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