A practical one-pot synthesis of chiral alcohols from readily available alkynes tandem catalysis by the combination of CFSOH and a fluorinated chiral diamine Ru(ii) complex in aqueous CFCHOH is described. Very interestingly, the combination of fluorinated catalysts and solvent exhibits a positive fluorine effect on the reactivity and enantioselectivity. A range of chiral alcohols with wide functional group tolerance was obtained in high yield and excellent stereoselectivity under simple and mild conditions.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9079948 | PMC |
| http://dx.doi.org/10.1039/c8ra02224k | DOI Listing |
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