We achieved the effective controllable regioselective acylation of the primary hydroxyl group of uridine derivatives catalyzed by Lipase TL IM from with excellent conversion and regioselectivity. Various reaction parameters were studied. These regioselective acylations performed in continuous flow microreactors are a proof-of-concept opening the use of enzymatic microreactors in uridine derivative biotransformations.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9079605 | PMC |
| http://dx.doi.org/10.1039/c8ra01030g | DOI Listing |
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