A novel and efficient scandium-catalyzed oxidative reaction between ynamides and alcohols for the facile synthesis of various α-alkoxyl amides is reported in this paper. The reaction avoids the need for the use of α-diazo carbonyls which are unstable and may cause some safety concerns. Instead, by using alkynes as the starting materials, this protocol features readily available substrates, compatibility with a broad range of functional groups, simple procedure, mild reaction conditions, and high chemoselectivity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9080523 | PMC |
| http://dx.doi.org/10.1039/c8ra03842b | DOI Listing |
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