A selective copper (Cu)-catalyzed C-S bond direct cross-coupling of thiols with 5-arylpenta-2,4-dienoic acid ethyl ester was developed. Notably, various biologically active 5-phenyl-3-phenylsulfanylpenta-2,4-dienoic acid ethyl ester derivatives were efficiently synthesized under moderate conditions. Finally, a plausible Cu(i)/Cu(iii) reaction mechanism was proposed.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9083087 | PMC |
| http://dx.doi.org/10.1039/c8ra05311a | DOI Listing |
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