AI Article Synopsis
- - An efficient method for alkylating indoles and electron-rich arenes using β-nitroalkenes in HFIP has been developed, leading to quick and high yields of products.
- - This process operates under mild conditions and doesn’t require extra catalysts or reagents, making it straightforward and clean.
- - It can also be utilized for the one-pot synthesis of tryptamine derivatives, which are important in biological applications.
Article Abstract
An effective and clean FC alkylation of indoles and electron-rich arenes with β-nitroalkenes in HFIP was reported. The desired products are formed rapidly in excellent yields under mild conditions without the need for any additional catalysts or reagents. Further, this methodology can be applied to one-pot synthesis of biologically active tryptamine derivatives.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9078892 | PMC |
| http://dx.doi.org/10.1039/c8ra01397g | DOI Listing |
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