A novel near-infrared fluorescent probe (L) based on a 1,4-diethyl-1,2,3,4-tetrahydro-7-pyrano[2,3-]quinoxalin-7-one scaffold has been synthesized and characterized. Probe L displays highly selective and sensitive recognition to HS over various anions and biological thiols with a large Stokes shift (125 nm) in THF/HO (6/4, v/v, Tris-HCl 10 mM, pH = 7.4). This probe exhibits turn-on fluorescence for HS through HS induced thiolysis of dinitrophenyl ether. Confocal laser scanning micrographs of MCF-7 cells incubated with L confirm that L is cell-permeable and can successfully detect HS in living cells.
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| http://dx.doi.org/10.1039/c8ra03457e | DOI Listing |
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