The synthesis of imidazo[1,5-]quinolines a decarboxylative cyclization under metal-free conditions.

RSC Adv

Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Soft Matter Chemistry & Center for Excellence in Molecular Synthesis of Chinese Academy of Sciences, Collaborative Innovation Center of Suzhou Nano Science and Technology & School of Chemistry and Materials Science, University of Science and Technology of China 230026 Hefei Anhui P. R. China +86-551-6360-3185.

Published: June 2018

An iodine-mediated decarboxylative cyclization was developed from α-amino acids and 2-methyl quinolines under metal-free conditions, affording a variety of imidazo[1,5-]quinolines with moderate to good yields.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081590PMC
http://dx.doi.org/10.1039/c8ra03786hDOI Listing

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