A novel route for the synthesis of 2-arylated quinolines through a [5 + 1] annulation directly from 2-methylquinolines and diynones under catalyst-free and solvent-free conditions was disclosed. This synthetic process was atom-economic, with good tolerance of a broad range of functional groups, and with great practical worth.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9077778 | PMC |
| http://dx.doi.org/10.1039/c7ra12716b | DOI Listing |
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