This study investigates the function of Elp1 and Elongator in the pituitary gland. Two conditional knockout models were generated where Elp1 was selectively deleted in either somatotropes of the anterior pituitary or Pomc-expressing cells of the anterior and intermediate pituitary. Although loss of Elp1 in somatotropes did not significantly impact murine growth or development, its loss in Pomc-expressing cells resulted in dramatically reduced levels of α-MSH, hyperphagia and obesity. This report provides the first evidence that Elongator plays an essential role in regulating the melanocortin satiety pathway.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9156574 | PMC |
| http://dx.doi.org/10.1016/j.bbrc.2022.04.128 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The lipocalin saga: Insights into its role in cancer-associated cachexia.
Biochim Biophys Acta Mol Basis Dis
January 2025
National Forensic Sciences University, Gandhinagar 382007, Gujarat, India. Electronic address:
Cancer-associated cachexia (CAC) is a debilitating condition, observed in patients with advanced stages of cancer. It is marked by ongoing weight loss, weakness, and nutritional impairment. Lower tolerance of chemotherapeutic agents and radiation therapy makes it difficult to treat CAC.
View Article and Find Full Text PDFExploring the therapeutic potential of precision medicine in rare genetic obesity disorders: a scientific perspective.
Front Nutr
December 2024
Faculty of Medicine, Diabetes Center, University of Geneva, Geneva, Switzerland.
The prevalence of obesity is increasing worldwide, affecting both children and adults. This obesity epidemic is mostly driven by an increase in energy intake (abundance of highly palatable energy-dense food and drinks) and to a lesser degree a decrease in energy expenditure (sedentary lifestyle). A small proportion of individuals with obesity are affected by genetic forms of obesity, which often relate to mutations in the leptin-melanocortin pathway or are part of syndromes such as the Bardet-Biedl syndrome.
View Article and Find Full Text PDFStochastic neuropeptide signals compete to calibrate the rate of satiation.
Nature
January 2025
Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Article Synopsis
- Neuropeptides play a crucial role in brain functions related to feeding and behavior, but many details about their interactions in the awake brain remain unclear.
- The study focuses on how specific neurons in the hypothalamus react to different neuropeptides to regulate eating and the feeling of fullness.
- Results show that the release of hunger-related and satiety-related neuropeptides can either compete or cooperate to control important signaling pathways, helping to gradually promote feelings of fullness during meals.
Carbocyclic setmelanotide analogs maintain biochemical potency at melanocortin 4 receptors.
J Pept Sci
February 2025
Department of Medicinal Chemistry, University of Kansas, Lawrence, Kansas, USA.
The melanocortin 4 receptor (MC4R) plays a critical role in satiety and energy homeostasis, and its dysregulation is implicated in numerous hyperphagic and obese disease states. Setmelanotide, a disulfide-based cyclic peptide, can rescue MC4R activity and treat obesities caused by genetic defects in MC4R signaling. But this peptide has moderate blood-brain barrier penetrance and metabolic stability, which can limit its efficacy in practice.
View Article and Find Full Text PDFStructure elucidation of a human melanocortin-4 receptor specific orthosteric nanobody agonist.
Nat Commun
October 2024
Confo Therapeutics N.V, Ghent, Belgium.
Article Synopsis
- The melanocortin receptor 4 (MC4R) is a crucial component in regulating hunger and fullness through its interaction with hormones like α-melanocyte-stimulating hormone and agouti-related peptide.
- Researchers developed a unique hybrid structure using a ConfoBody that helps them discover a variety of MC4R-specific, potent nanobodies that act as full agonists.
- The study revealed the structure of MC4R with a full agonistic nanobody at a high resolution, showing that this specific nanobody could potentially be more effective and targeted for anti-obesity treatments compared to existing peptide agonists.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!