Borane-catalyzed arylation of aryldiazoacetates with ,-dialkylanilines.

Org Biomol Chem

Hubei Collaborative Innovation Centre for Advanced Organic Chemical Materials, College of Chemistry and Chemical Engineering, Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, Hubei University, Wuhan, 430062, P. R. China.

Published: May 2022

AI Article Synopsis

  • A new reaction method has been created for selectively combining donor-acceptor diazo compounds with aniline derivatives.
  • This process is catalyzed by Lewis acidic boranes, making it straightforward and efficient.
  • The resulting reaction produces diarylacetates without the need for metal catalysts, which is a cleaner approach.

Article Abstract

A selective arylation of donor-acceptor diazo compounds with aniline derivatives catalyzed by Lewis acidic boranes is developed. This simple reaction protocol provides an efficient method for the synthesis of diarylacetates under metal-free conditions.

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Source
http://dx.doi.org/10.1039/d2ob00447jDOI Listing

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