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[Use of hydroxychloroquine in recurrent immune-mediated obstetric diseases (excluding systemic lupus): Scientific basis and evidence].
Rev Med Interne
December 2024
Service de médecine interne et inflammation, département inflammation-immunopathologie-biothérapie (DMU I3), CEREMAIAA, hôpital Saint-Antoine, AP-HP, Sorbonne université, Paris, France.
Hydroxychloroquine (HCQ), a synthetic antimalarial, is recognized for its immunomodulatory, anti-inflammatory and vascular-protective effects. In 20-30% of cases of primary obstetrical antiphospholipid syndrome (APS), the combination of antiplatelet aggregation and prophylactic anticoagulation fails to prevent obstetrical complications, a situation referred to as refractory obstetrical APS. This is partly due to the pro-inflammatory effects of antiphospholipid antibodies (aPL) binding to decidual and trophoblastic cells, which compromise embryonic implantation and placentation.
View Article and Find Full Text PDFNegotiating Care: The Biographical Narratives of Young Adults Who Questioned Their Gender When Younger.
Sociol Health Illn
January 2025
Department of Sociology, University of York, York, UK.
Current discussions about gender identity are increasingly politicised, particularly in the UK. An individual's body becomes a site of competing interests that attempt to regulate the physical, social and moral boundaries between biological sex and a socially realised gender. Care becomes defined within this context.
View Article and Find Full Text PDFCost-effectiveness analysis of 9-valent human papillomavirus vaccine combined with screening for cervical cancer in Japan.
Int J Gynaecol Obstet
December 2024
Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, Tokyo, Japan.
Objective: In Japan, the current coverage rate of human papillomavirus (HPV) vaccination is only 30%, and the rate of biennial cervical screening is 40%. The Japanese Government has attempted to increase the coverage of HPV vaccination and cervical screening. We analyzed the cost-effectiveness of the 9-valent HPV vaccine and cervical screening in Japan.
View Article and Find Full Text PDFRelationship between lipid levels, TyG, TyG-BMI index and hypertension in Tibetan population in Tibet, China based on restricted cubic spline model.
BMC Public Health
December 2024
Medical College of Tibet University, No. 10 East Zangda Road,Chengguan District, Lhasa, 850000, China.
Background: The prevalence of hypertension among the Tibetan population in Tibet is higher than in other regions of China, and there is a lack of unified epidemiological surveys. This study aims to conduct a standardized epidemiological investigation to assess the current status of hypertension among the Tibetan population, as well as to explore the dose-response relationship between cholesterol (TC), triglyceride glucose index (TyG), triglyceride glucose-body mass index (TyG-BMI), and hypertension in this population.
Methods: From June 2020 to July 2023, a total of 5042 Tibetans aged 18 to 80 years from three cities and one region in Tibet were randomly sampled for the study.
Dentists' views on the role orientation of dental hygienists in China: A qualitative content analysis.
BMC Oral Health
December 2024
Department of Stomatology, the 960th hospital of People's Liberation Army of China (PLA), Jinan, China.
Background: A dental hygienist is an indispensable auxiliary staff in stomatology who assists people in achieving an optimum level of oral health. Despite advancements in dental medical services, our country has not yet established the position of dental hygienists. The current imbalance in the allocation of dental human resources has created a significant disparity between the demand for and supply of dental auxiliaries.
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