Light-Propelled Nanorobots for Facial Titanium Implants Biofilms Removal.

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Future Energy and Innovation Laboratory, Central European Institute of Technology, Brno University of Technology, Purkyňova 123, Brno, 612 00, Czech Republic.

Published: June 2022

AI Article Synopsis

  • Titanium miniplates are used in oral and maxillofacial surgery to treat bone fractures but often need removal due to complications like biofilm formation, which leads to inflammation and implant failure.
  • Researchers are investigating the use of light-driven nanorobots to combat bacterial biofilms on these titanium implants, simulating conditions found in the mouth.
  • The study found that these nanorobots, which operate under different wavelengths of light, can effectively reduce biofilm biomass, suggesting a promising new treatment for infections related to metallic implants.

Article Abstract

Titanium miniplates are biocompatible materials used in modern oral and maxillofacial surgery to treat facial bone fractures. However, plate removal is often required due to implant complications. Among them, a biofilm formation on an infected miniplate is associated with severe inflammation, which frequently results in implant failure. In light of this, new strategies to control or treat oral bacterial biofilm are of high interest. Herein, the authors exploit the ability of nanorobots against multispecies bacterial biofilm grown onto facial commercial titanium miniplate implants to simulate pathogenic conditions of the oral microenvironment. The strategy is based on the use of light-driven self-propelled tubular black-TiO /Ag nanorobots, that unlike traditional ones, exhibit an extended absorption and motion actuation from UV to the visible-light range. The motion analysis is performed separately over UV, blue, and green light irradiation and shows different motion behaviors, including a fast rotational motion that decreases with increasing wavelengths. The biomass reduction is monitored by evaluating LIVE/DEAD fluorescent and digital microscope images of bacterial biofilm treated with the nanorobots under motion/no-motion conditions. The current study and the obtained results can bring significant improvements for effective therapy of infected metallic miniplates by biofilm.

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Source
http://dx.doi.org/10.1002/smll.202200708DOI Listing

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