AI Article Synopsis
- Researchers have developed a fully integrated wearable microneedle array that continuously monitors metabolites like lactate and glucose in interstitial fluid, enhancing ease of use during daily activities.
- The device features a custom smartphone app for data capture and visualization, reusable electronics, and disposable microneedle arrays, ensuring pain-free skin penetration and effective system integration.
- Preliminary results show that the device's measurements correlate well with traditional blood and breath tests, but further large-scale validation is necessary to confirm its effectiveness for real-time monitoring of multiple biomarkers.
Article Abstract
Implementations of wearable microneedle-based arrays of sensors for the monitoring of multiple biomarkers in interstitial fluid have lacked system integration and evidence of robust analytical performance. Here we report the development and testing of a fully integrated wearable array of microneedles for the wireless and continuous real-time sensing of two metabolites (lactate and glucose, or alcohol and glucose) in the interstitial fluid of volunteers performing common daily activities. The device works with a custom smartphone app for data capture and visualization, comprises reusable electronics and a disposable microneedle array, and is optimized for system integration, cost-effective fabrication via advanced micromachining, easier assembly, biocompatibility, pain-free skin penetration and enhanced sensitivity. Single-analyte and dual-analyte measurements correlated well with the corresponding gold-standard measurements in blood or breath. Further validation of the technology in large populations with concurrent validation of sensor readouts through centralized laboratory tests should determine the robustness and utility of real-time simultaneous monitoring of several biomarkers in interstitial fluid.
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| http://dx.doi.org/10.1038/s41551-022-00887-1 | DOI Listing |
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