AI Article Synopsis
- Cerebrovascular disease may contribute to late-life depression, but existing evidence linking neuroimaging indicators with depressive symptoms is mixed. This study analyzed a large group of middle-aged and elderly individuals over time to clarify these connections.
- In a population of 4943 participants, findings revealed that smaller total brain volume, larger white matter hyperintensities, and the presence of cortical infarcts were associated with higher depressive symptoms at both initial assessments and over time.
- The study concluded that damage to white matter structures significantly correlated with increasing depressive symptoms, especially among older adults, highlighting the importance of brain health in mental well-being as people age.
Article Abstract
Background: Cerebrovascular disease is regarded as a potential cause of late-life depression. Yet, evidence for associations of neuroimaging markers of vascular brain disease with depressive symptoms is inconclusive. We examined the associations of neuroimaging markers and depressive symptoms in a large population-based study of middle-aged and elderly persons over time.
Methods: A total of 4943 participants (mean age = 64.6 ± 11.1 years, 55.7% women) from the Rotterdam Study were included. At baseline, total brain volume, gray matter volume, white matter volume, white matter hyperintensities volume, cortical infarcts, lacunar infarcts, microbleeds, white matter fractional anisotropy, and mean diffusivity (MD) were measured with a brain MRI (1.5T). Depressive symptoms were assessed twice with the Center for Epidemiologic Studies Depression scale (median follow-up time: 5.5 years, IQR = 0.9). To assess temporal associations of neuroimaging markers and depressive symptoms, linear mixed models were used.
Results: A smaller total brain volume ( = -0.107, 95% CI -0.192 to -0.022), larger white matter hyperintensities volume ( = 0.047, 95% CI 0.010-0.084), presence of cortical infarcts ( = 0.194, 95% CI 0.047-0.341), and higher MD levels ( = 0.060, 95% CI 0.022-0.098) were cross-sectionally associated with more depressive symptoms. Longitudinal analyses showed that small total brain volume ( = -0.091, 95% CI -0.167 to -0.015) and presence of cortical infarcts ( = 0.168, 95% CI 0.022-0.314) were associated with increasing depressive symptoms over time. After stratification on age, effect sizes were more pronounced at older ages.
Conclusions: Neuroimaging markers of white matter microstructural damage were associated with depressive symptoms longitudinally in this study of middle-aged and elderly persons. These associations were more pronounced at older ages, providing evidence for the role of white matter structure in late-life depressive symptomatology.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10388307 | PMC |
| http://dx.doi.org/10.1017/S003329172200112X | DOI Listing |
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