[Research progress of Curcuma kwangsiensis root tubers and analysis of liver protection and anti-tumor mechanisms based on Q-markers].

Zhongguo Zhong Yao Za Zhi

China-ASEAN Joint Laboratory for International Cooperation in Traditional Medicine Research, Guangxi University of Chinese Medicine Nanning 530200, China Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica Nanning 530200, China Guangxi Key Laboratory of Traditional Chinese Medicine Rheumatism Prescription Theory and Transformation Nanning 530200, China Guangxi Scientific Research Center of Traditional Chinese Medicine Nanning 530200, China.

Published: April 2022

AI Article Synopsis

  • Curcuma kwangsiensis root tuber is a traditional medicinal herb in Guangxi known for its active compounds, mainly terpenoids and curcumins, which aid in pain relief, mood enhancement, liver function, and anti-jaundice effects.
  • Modern studies highlight its health benefits, including liver protection, anti-tumor properties, and antioxidant activities.
  • The research identifies potential quality markers and key biological pathways related to its medicinal effects, serving as a foundation for further studies and product development in traditional Chinese medicine.

Article Abstract

Curcuma kwangsiensis root tuber is a widely used genuine medicinal material in Guangxi, with the main active components of terpenoids and curcumins. It has the effects of promoting blood circulation to relieve pain, moving Qi to relieve depression, clearing heart and cooling blood, promoting gallbladder function and anti-icterus. Modern research has proved its functions in liver protection, anti-tumor, anti-oxidation, blood lipid reduction and immunosuppression. Considering the research progress of C. kwangsiensis root tubers and the core concept of quality marker(Q-marker), we predicted the Q-markers of C. kwangsiensis root tubers from plant phylogeny, chemical component specificity, traditional pharmacodynamic properties, new pharmacodynamic uses, chemical component measurability, processing methods, compatibility, and components migrating to blood. Curcumin, curcumol, curcumadiol, curcumenol, curdione, germacrone, and β-elemene may be the possible Q-markers. Based on the predicted Q-markers, the mechanisms of the liver-protecting and anti-tumor activities of C. kwangsiensis root tubers were analyzed. AKT1, IL6, EGFR, and STAT3 were identified as the key targets, and neuroactive ligand-receptor interaction signaling pathway, nitrogen metabolism pathway, cancer pathway, and hepatitis B pathway were the major involved pathways. This review provides a basis for the quality evaluation and product development of C. kwangsiensis root tubers and gives insights into the research on Chinese medicinal materials.

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Source
http://dx.doi.org/10.19540/j.cnki.cjcmm.20211220.203DOI Listing

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