[Analysis and prediction of quality markers of Lonicerae Japonicae Flos].

Zhongguo Zhong Yao Za Zhi

Tianjin Key Laboratory of Quality Marker of Traditional Chinese Medicine, Tianjin Institute of Pharmaceutical Research Tianjin 300301, China State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research Tianjin 300301, China.

Published: April 2022

AI Article Synopsis

  • Lonicerae Japonicae Flos is a traditional Chinese medicine used for centuries to treat inflammation and infections due to its complex chemical composition.
  • The study focuses on developing a quality assessment method using quality markers (Q-markers) to evaluate the medicinal quality comprehensively.
  • Key chemical compounds identified as potential Q-markers include chlorogenic acid, isochlorogenic acids A, B, and C, luteoloside, rutin, sweroside, and secoxyloganin.

Article Abstract

Lonicerae Japonicae Flos, as common Chinese medicine, has been used for thousands of years in the treatment of inflammation and infectious diseases with definite efficacies. The complex composition of Lonicerae Japonicae Flos results in its extensive pharmacological effects, so the assessment of its quality by only a few index components is not comprehensive. Guided by the quality marker(Q-marker), the present study comprehensively analyzed and predicted the quality connotation of Lonicerae Japonicae Flos based on the chemical composition and component transfer, the phylogenetic relationship, chemical composition effectiveness, measurability, and specificity. Chlorogenic acid, isochlorogenic acids A, B, and C, luteoloside, rutin, sweroside, and secoxyloganin were predicted as candidate Q-markers of Lonicerae Japonicae Flos.

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Source
http://dx.doi.org/10.19540/j.cnki.cjcmm.20211224.201DOI Listing

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