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Association of a multiplex immune marker panel with incident cognitive impairment and dementia: The Northern Manhattan Study.
Brain Behav Immun Health
February 2025
Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Objective: To determine whether a panel of immune markers adds significant information to known correlates of risk of dementia and cognitive impairment.
Background: The impact of immune mechanisms on dementia risk is incompletely characterized.
Design/methods: A subsample of the Northern Manhattan Study, a prospective cohort study in the racially/ethnically diverse population of New York City, underwent comprehensive neuropsychological testing up to three times, at approximately 5-year intervals.
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer, with Hispanic/Latino children having a higher incidence of ALL than other racial/ethnic groups. Genetic variants, particularly ones found enriched in Indigenous American (IA)-like ancestry and inherited by Hispanics/Latinos, may contribute to this disparity. In this study, we characterized the impact of IA-like ancestry on overall ALL risk and the frequency and effect size of known risk alleles in a large cohort of self-reported Hispanic/Latino individuals.
View Article and Find Full Text PDF: The chronic kidney disease (CKD) burden in the US varies by race/ethnicity. It was unclear whether nativity status influences these disparities. This study compared CKD prevalence by nativity status, race and ethnicity, and length of US residence.
View Article and Find Full Text PDFStill not There yet: Persistence of Racial and Ethnic Disparities in Declining Cancer Surgery.
Ann Surg
January 2025
Department of Surgery, Brigham and Women's Hospital, Boston, MA, USA.
Prevalence of female hirsutism and PCOS in the United States: A cross-sectional study.
J Dtsch Dermatol Ges
January 2025
Department of Dermatology, Stony Brook University Medical Center, Stony Brook, New York, USA.
Background: Current research on hirsutism reveals disparities and knowledge deficiencies, particularly in underrepresented cohorts. Our objective is to scrutinize demographic variances in hirsutism rates.
Patients And Methods: Using the All of Us database, we conducted a cross-sectional analysis encompassing 172,401 women.
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