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Longitudinal assessment of colonoscopy adverse events in the prospective Cooperative Studies Program no. 380 colorectal cancer screening and surveillance cohort. | LitMetric

AI Article Synopsis

  • The study evaluated the risk of adverse events during long-term follow-up of a colonoscopy screening program for colorectal cancer among asymptomatic veterans aged 50 to 75.
  • Out of 3727 follow-up examinations, adverse events occurred in 2.8% of cases, with major events including one perforation and three gastrointestinal bleeds.
  • The findings suggest that overall, the colonoscopy screening is safe, but previous adverse events and comorbid conditions should be carefully considered to guide further follow-up decisions.

Article Abstract

Background And Aims: Data are limited regarding colonoscopy risk during long-term, programmatic colorectal cancer screening and follow-up. We aimed to describe adverse events during follow-up in a colonoscopy screening program after the baseline examination and examine factors associated with increased risk.

Methods: Cooperative Studies Program no. 380 includes 3121 asymptomatic veterans aged 50 to 75 years who underwent screening colonoscopy between 1994 and 1997. Periprocedure adverse events requiring significant intervention were defined as major events (other events were minor) and were tracked during follow-up for at least 10 years. Multivariable odds ratios (ORs) were calculated for factors associated with risk of follow-up adverse events.

Results: Of 3727 follow-up examinations in 1983 participants, adverse events occurred in 105 examinations (2.8%) in 93 individuals, including 22 major and 87 minor events (examinations may have had >1 event). Incidence of major events (per 1000 examinations) remained relatively stable over time, with 6.1 events at examination 2, 4.8 at examination 3, and 7.2 at examination 4. Examinations with major events included 1 perforation, 3 GI bleeds requiring intervention, and 17 cardiopulmonary events. History of prior colonoscopic adverse events was associated with increased risk of events (major or minor) during follow-up (OR, 2.7; 95% confidence interval, 1.6-4.6).

Conclusions: Long-term programmatic screening and surveillance was safe, as major events were rare during follow-up. However, serious cardiopulmonary events were the most common major events. These results highlight the need for detailed assessments of comorbid conditions during routine clinical practice, which could help inform individual decisions regarding the utility of ongoing colonoscopy follow-up.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531542PMC
http://dx.doi.org/10.1016/j.gie.2022.04.1343DOI Listing

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