Severity: Warning
Message: file_get_contents(https://...@pubfacts.com&api_key=b8daa3ad693db53b1410957c26c9a51b4908&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
Filename: helpers/my_audit_helper.php
Line Number: 176
Backtrace:
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 176
Function: file_get_contents
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 250
Function: simplexml_load_file_from_url
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 1034
Function: getPubMedXML
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3152
Function: GetPubMedArticleOutput_2016
File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global
File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword
File: /var/www/html/index.php
Line: 316
Function: require_once
Clinical Relevance: That myopic defocus, even if restricted to the peripheral retina, inhibits eye growth in young monkey eyes has motivated the therapy of myopia control through multifocal contact lens wear in children.
Background: To understand how eye-length regulating mechanisms are triggered by light requires knowledge of retinal light spread. That is largely lacking for the multifocal contact lenses used in the therapy because empirical methods identifying just the defocus in dioptres are inadequate.
Methods: "Through-focus" diffraction computations in contact lens/eye models with typical normal eye parameters, including polychromatic light, the chromatic aberrations and an -cone phototransduction layer, offer estimates of retinal image spread for a range of viewing distances.
Results: Point- and edge-spread distributions of activation of phototransduction in the central retina show that the addition of multifocal zones produces some veiling for in-focus viewing and substantial improvement of image quality for near targets in the unaccommodated eye. These effects are much reduced in the retinal periphery.
Conclusion: Whatever therapeutic value there is in prescribing multifocal contact lenses for myopia control, it is not particularly dependent on the precise configuration of the multifocal zones, nor can it be ascribed to changes in image quality specific to the retinal periphery; its origin is more likely less blur for near targets, reducing the stimulus to accommodation.
Download full-text PDF |
Source |
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http://dx.doi.org/10.1080/08164622.2022.2074290 | DOI Listing |
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