Background: COVID-19 is a disease with high mortality worldwide, and which parameters that affect mortality in intensive care are still being investigated. This study aimed to show the factors affecting mortality in COVID-19 intensive care patients and write a model that can predict mortality.
Methods: The data of 229 patients in the COVID-19 intensive care unit were scanned. Laboratory tests, APACHE, SOFA, and GCS values were recorded. CT scores were calculated with chest CTs. The effects of these data on mortality were examined. The effects of the variables were modeled using the stepwise regression method.
Results: While the mean age of female (30.14%) patients was 69.1 ± 12.2, the mean age of male (69.86%) patients was 66.9 ± 11.5. The mortality rate was 69.86%. Age, CRP, D-dimer, creatinine, procalcitonin, APACHE, SOFA, GCS, and CT score were significantly different in the deceased patients than the survival group. When we attempted to create a model using stepwise linear regression analysis, the appropriate model was achieved at the fourth step. Age, CRP, APACHE, and CT score were included in the model, which has the power to predict mortality with 89.9% accuracy.
Conclusion: Although, when viewed individually, there is a significant difference in parameters such as creatinine, procalcitonin, D-dimer, GCS, and SOFA score, the probability of mortality can be estimated by knowing only the age, CRP, APACHE, and CT scores. These four simple parameters will help clinicians effectively use resources in treatment.
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http://dx.doi.org/10.1016/j.clinimag.2022.04.017 | DOI Listing |
Braz J Otorhinolaryngol
January 2025
Shanghai Jiao Tong University, School of Medicine, Hainan Branch of Shanghai Children's Medical Center, Department of Otorhinolaryngology, Sanya, China; Shanghai Jiao Tong University, School of Medicine, Shanghai Children's Medical Center, Department of Otorhinolaryngology, Shanghai, China. Electronic address:
Objective: We aimed to investigate the correlation between prevalent risk factors for high-risk neonates in neonatal intensive care unit and their hearing loss, and to examine the audiological features and genetic profiles associated with different deafness mutations in our tertiary referral center. This research seeks to deepen our understanding of the etiology behind congenital hearing loss.
Methods: We conducted initial hearing screenings, including automated auditory brainstem response, distortion product otoacoustic emission, and acoustic immittance on 443 high-risk neonates within 7 days after birth and 42 days (if necessary) after birth.
Asia Pac J Clin Oncol
January 2025
Department of Respiratory and Critical Care Medicine, Peking University People's Hospital, Beijing, China.
Purpose: Our study aims to evaluate the characteristics of serum soluble PD-1 (sPD-1) and soluble PD-L1 (sPD-L1) levels and their correlations with immune status and prognosis in advanced lung cancer patients.
Methods: Patients diagnosed with advanced lung cancer based on histology or cytology in Peking University People's Hospital from July 2020 to November 2021 were enrolled. Clinicopathological data were recorded and analyzed.
Adv Ther
January 2025
Personalized Medicine, Asthma and Allergy, IRCCS Humanitas Clinical and Research Hospital, Via Alessandro Manzoni 56, 20089, Rozzano, MI, Italy.
Introduction: The burden of severe asthma on patients, especially on those with concomitant chronic rhinosinusitis with nasal polyps (CRSwNP), is substantial. Treatment intensification with oral corticosteroids is a common strategy for managing severe asthma exacerbations; however, prolonged exposure to systemic corticosteroids is associated with multisystem toxicity. This study aimed to quantify the association between oral corticosteroid use and annual asthma-related costs in patients with severe asthma with or without CRSwNP.
View Article and Find Full Text PDFPharmacoeconomics
January 2025
Centre for Health Economics Research and Evaluation, University of Technology Sydney, PO Box 123, Broadway, NSW, 2007, Australia.
Background: Cost-utility analyses commonly use two primary methods to value productivity: the human capital approach (HCA) and the friction cost approach (FCA). Another less frequently used method is the willingness-to-pay (WTP) approach, which estimates the monetary value individuals assign to avoiding an illness. In the context of foodborne illnesses (FBI), productivity loss represents one of the most significant economic impacts, particularly in developed nations.
View Article and Find Full Text PDFCurr Pain Headache Rep
January 2025
Department of Anesthesiology, Critical Care, and Pain Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA.
Purpose Of Review: Complex regional pain syndrome (CRPS) is a chronic condition characterized by disproportional pain typically affecting an extremity. Management of CRPS is centered around specific symptomatology, which tends to be a combination of autonomic dysfunction, nociceptive sensitization, chronic inflammation, and/or motor dysfunction. Targeting the autoimmune component of CRPS provides a way to both symptomatically treat as well as minimize progression of CRPS.
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