AI Article Synopsis
- Microsporum gypseum is a type of fungus that typically lives in the soil and can cause skin issues in healthy individuals, but can lead to more severe conditions in those with weakened immune systems.
- A case is presented where a patient exhibited extensive skin lesions caused by multiple fungi, including Candida sp, but initially had poor treatment response with standard antifungal medications.
- Upon further investigation, the patient was found to have a specific immune deficiency (STAT1-GOF), and after being treated with a systemic antifungal, saw improvement in their skin lesions.
Article Abstract
Microsporum gypseum is a geophilic fungus that can cause inflammatory skin lesions in heathy people. More extensive lesions have been described in immunocompromised patients. We present a patient with extensive dermatophytosis, which mycological examination led the identification of Candida sp, Epidermophyton Floccosum and Trichophyton tonsurans and showed poor response to treatment with griseofulvina and itraconazol at usual doses. When skin biopsy was performed, it had positive culture for M. gypseum. Due to the extension and poor response to treatment, immunological assessment was performed and it showed a defect of STAT1 with gain of function (STAT 1-GOF). Patients with primary immunodeficiency are susceptible to fungal infections, especially Candida but also virus and bacteria, although to a lesser extent. The patient received long-term treatment with systemic imidazole antifungal recovering for the lesions.
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| http://dx.doi.org/10.5546/aap.2022.e128 | DOI Listing |
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