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Socioeconomic position, alcohol use and alcohol-attributable emergency department visits.
J Epidemiol Community Health
December 2024
Public Health Ontario, Toronto, Ontario, Canada.
Background: Differential vulnerability to alcohol contributes to socioeconomic inequities in alcohol-attributable harm. This study aimed to estimate the sex-/gender-specific joint effects of socioeconomic position (SEP) and heavy episodic drinking or volume of alcohol use on 100% alcohol-attributable emergency department (ED) visits.
Methods: We conducted a cohort study among 36 900 men and 39 700 women current and former alcohol consumers aged 15-64 from population-representative Canadian Community Health Surveys (2003-2008) linked to administrative ED visit data through 2017 in Ontario and Alberta.
Robust, fully-automated assessment of cerebral perivascular spaces and white matter lesions: a multicentre MRI longitudinal study of their evolution and association with risk of dementia and accelerated brain atrophy.
EBioMedicine
December 2024
Department of Neurosurgery, Stanford University, Stanford, CA, USA.
Background: Perivascular spaces (PVS) on brain MRI are surrogates for small parenchymal blood vessels and their perivascular compartment, and may relate to brain health. However, it is unknown whether PVS can predict dementia risk and brain atrophy trajectories in participants without dementia, as longitudinal studies on PVS are scarce and current methods for PVS assessment lack robustness and inter-scanner reproducibility.
Methods: We developed a robust algorithm to automatically assess PVS count and size on clinical MRI, and investigated 1) their relationship with dementia risk and brain atrophy in participants without dementia, 2) their longitudinal evolution, and 3) their potential use as a screening tool in simulated clinical trials.
Brief Report: Protease Inhibitors Versus Nonnucleoside Reverse Transcriptase Inhibitors and the Risk of Cancer Among People With HIV.
J Acquir Immune Defic Syndr
August 2024
Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Background: The effect of initial antiretroviral therapy (ART) class on cancer risk in people with HIV (PWH) remains unclear.
Setting: Cohort study of 36,322 PWH enrolled (1996-2014) in the North American AIDS Cohort Collaboration on Research and Design.
Methods: We followed individuals from ART initiation (protease inhibitor [PI]-, non-nucleoside reverse transcriptase inhibitor [NNRTI]-, or integrase strand transfer inhibitor [INSTI]-based) until incident cancer, death, loss-to-follow-up, 12/31/2014, 85 months (intention-to-treat analyses [ITT]), or 30 months (per-protocol [PP] analyses).
Perspectives of Canadian Plastic Surgeons on the Surgical Management of Pressure Injuries.
Plast Surg (Oakv)
December 2024
Ross Tilley Burn Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Pressure injuries, particularly among patients with spinal cord injuries and the elderly, significantly contribute to morbidity, mortality, and financial sequelae. Surgical interventions, including debridement and flaps, may improve outcomes, especially for stage 3 and 4 pressure injuries. This survey assesses Canadian plastic surgeons' perspectives and practices regarding the surgical management of these injuries.
View Article and Find Full Text PDFAre E-Cigarettes Substitutes or Complements to Combustible Cigarettes Among Youths? Evidence From Canada.
Health Econ
December 2024
College of Pharmacy, University of Manitoba, Winnipeg, Canada.
Existing evidence on whether e-cigarettes are substitutes or complements to combustible cigarettes is limited and mixed. We revisit this question using nationally-representative Canadian survey data over 14 years (2004-2017) and difference-in-differences methods that exploit the staggered adoption of e-cigarette Minimum Legal Age (MLA) laws in Canadian provinces between 2015 and 2017. We study the laws' effects not only on youth smoking but also on smoking initiation and cessation to shed light on the mechanisms through which these laws affect youth smoking.
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