[This corrects the article DOI: 10.1039/D0RA02848G.].
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http://dx.doi.org/10.1039/d0ra90067b | DOI Listing |
J Gastroenterol Hepatol
January 2025
Department of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan.
Background And Aim: Qualitative diagnosis of ulcerative colitis-associated neoplasia (UCAN) is crucial for surveillance colonoscopy in patients with ulcerative colitis (UC). Although the utility of magnifying endoscopy with narrow-band imaging (ME-NBI) in sporadic neoplasia diagnosis has been reported, its efficacy in UCAN remains unclear. This study aimed to evaluate the usefulness of ME-NBI for qualitative diagnosis of UCAN.
View Article and Find Full Text PDFMol Syst Biol
January 2025
Department of Pathology and Cell Biology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, 10032, USA.
With current treatments addressing only a fraction of pathogens and new viral threats constantly evolving, there is a critical need to expand our existing therapeutic arsenal. To speed the rate of discovery and better prepare against future threats, we establish a high-throughput platform capable of screening compounds against 40 diverse viral proteases simultaneously. This multiplex approach is enabled by using cellular biosensors of viral protease activity combined with DNA-barcoding technology, as well as several design innovations that increase assay sensitivity and correct for plate-to-plate variation.
View Article and Find Full Text PDFSci Rep
January 2025
Young Researchers and Elite Club, Omidiyeh Branch, Islamic Azad University, Omidiyeh, Iran.
Accurate estimation of interfacial tension (IFT) between nitrogen and crude oil during nitrogen-based gas injection into oil reservoirs is imperative. The previous research works dealing with prediction of IFT of oil and nitrogen systems consider synthetic oil samples such n-alkanes. In this work, we aim to utilize eight machine learning methods of Decision Tree (DT), AdaBoost (AB), Random Forest (RF), K-nearest Neighbors (KNN), Ensemble Learning (EL), Support Vector Machine (SVM), Convolutional Neural Network (CNN) and Multilayer Perceptron Artificial Neural Network (MLP-ANN) to construct data-driven intelligent models to predict crude oil - nitrogen IFT based upon experimental data of real crude oils samples encountered in underground oil reservoirs.
View Article and Find Full Text PDFJ Inherit Metab Dis
January 2025
Department of Pediatrics, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Gyrate atrophy of the choroid and retina (GACR, OMIM #258870) is a rare inherited metabolic disorder characterized by progressive chorioretinal degeneration and hyperornithinemia. Current therapeutic modalities potentially slow disease progression but are not successful in preventing blindness. To allow for trial development, increased knowledge of the clinical phenotype and current therapeutic outcomes is required.
View Article and Find Full Text PDFAging (Albany NY)
December 2024
Department of Oncology, Jiujiang University Affiliated Hospital, Jiujiang 332000, P.R. China.
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