A formal, stereocontrolled synthesis of lactacystin has been completed from -Bul-serine, providing the key intermediate 13, also useful for the generation of a range of C-9 analogues.
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| http://dx.doi.org/10.1039/c9ra07244f | DOI Listing |
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Introduction: Urinary incontinence is associated with social isolation, deconditioning, depression, falls and early mortality. It impairs quality of life, even in residents of nursing homes, and, in the community, increases the risk of institutionalisation. Care focused on the preservation of dignity during intimate care is important in the care of older adults.
View Article and Find Full Text PDFVascular Ehlers-Danlos syndrome in children: evaluating the importance of diagnosis and follow-up during childhood.
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December 2024
National EDS Service, London North West University Healthcare NHS Trust, London, UK.
Vascular Ehlers-Danlos syndrome (vEDS) is a rare inherited connective tissue disorder predominantly caused by pathogenic COL3A1 variants. Characteristic arterial and intestinal fragility and generalised severe tissue friability can lead to clinical events from childhood. We highlight a paucity of literature regarding children diagnosed with vEDS, possibly explained by a restraint in predictive testing, and present data on 63 individuals (23 index cases) with a clinical and genetic diagnosis of vEDS in childhood (<18 years) to address this.
View Article and Find Full Text PDFHow to Encourage the Public to Help People With Dementia in the Community: A Scoping Review.
J Adv Nurs
December 2024
School of Nursing, Jilin University, Changchun, Jilin, People's Republic of China.
Background: In a response to the lack of public awareness of dementia, 'ageing in place' and 'dementia-friendly community' policies have been proposed, and a number of relevant studies have been carried out.
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The Reproducibility and Reliability of Insulin Sensitivity and Secretion Indices in Children and Adolescents.
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Department of Pediatrics, Division of Pediatric Endocrinology, University of Michigan, Ann Arbor, USA.
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Visible-Light Induced and Iron Peroxo-Promoted Radical Difunctionalization of Alkene for the Synthesis of β-Ketosulfone and α-Chloroketone.
J Org Chem
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College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing 314001, Zhejiang, China.
In this work, a switchable synthesis of β-ketosulfone and α-chloroketone through a radical difunctionalization of alkenes is reported. The transformation works well under iron peroxo species/photoredox dual catalysis and an open-flask atmosphere, and the reaction is highlighted with good yields and a broad reaction scope. Mechanism studies show that the reaction is initiated by a formal [4 + 2] cyclization of the sulfonyl radical in a regioselective manner.
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