Compulsive behaviors rarely lead to significant physical injury, but when they do, they can introduce challenges in treatment secondary to diagnostic uncertainty and introduce ethical and legal dilemmas when trying to optimize patient care. We discuss the clinical complexities in treating a patient with compulsive neck cracking as she navigates various clinical settings in hopes of alleviating the anxiety and pain that lead to her behaviors. Ultimately, the principles of beneficence and autonomy must be weighed when determining whether someone with a chronic risk of serious physical harm from compulsive behaviors requires involuntary psychiatric treatment.
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http://dx.doi.org/10.7759/cureus.23875 | DOI Listing |
Clin Epigenetics
January 2025
Faculty of Medicine of TUD Dresden University of Technology, Institute for Clinical Genetics, University Hospital Carl Gustav Carus at TUD Dresden University of Technology, Dresden, Germany.
Autosomal dominant CDK13-related disease is characterized by congenital heart defects, dysmorphic facial features, and intellectual developmental disorder (CHDFIDD). Heterozygous pathogenic variants, particularly missense variants in the kinase domain, have previously been described as disease causing. Using the determination of a methylation pattern and comparison with an established episignature, we reveal the first hypomorphic variant in the kinase domain of CDK13, leading to a never before described autosomal recessive form of CHDFIDD in a boy with characteristic features.
View Article and Find Full Text PDFPsychiatry Res
January 2025
Department of Neuropsychiatry, Graduate School of Medicine, Kyoto University, Japan; Artificial Intelligence Ethics and Society Team, RIKEN Center for Advanced Intelligence Project, Saitama, Japan; The General Research Division, Osaka University Research Center on Ethical, Legal and Social Issues, Kyoto, Japan. Electronic address:
Background: Our human volumetric MRI study (Dai et al., 2024) demonstrated that habenula (Hb) volume is associated with psychological resilience, a key protective factor against depression. However, the biological mechanisms underpinning this relationship remain unclear.
View Article and Find Full Text PDFPilot Feasibility Stud
January 2025
Department of Health Service & Population Research, David Goldberg Centre, King's College London, Denmark Hill, London, UK.
Background: Mental health disorders are one of the leading causes of illness globally. The importance of psychosocial skills acquired in early childhood, such as executive functions, inhibitory control, emotional regulation, and social problem-solving, in preventing mental disorders has been reported. Furthermore, mental health care delivery is evolving, and mobile technology is becoming the medium for assessment and intervention.
View Article and Find Full Text PDFBMC Oral Health
January 2025
Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, Nørre Allé 20, Copenhagen, 2200, Denmark.
Background: A large number of older people depend on others for help with their daily personal care, including oral health care. Nursing home and elder-care staff often face challenges identifying older people, who are exposed to or at an increased risk of oral diseases. Thus, the aim of this study was to identify risk factors that non-dental care staff can use to identify older people at risk of oral diseases and poor oral hygiene.
View Article and Find Full Text PDFBMC Anesthesiol
January 2025
Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, School of Medicine, Zhongda Hospital, Southeast University, Nanjing, 210009, China.
Background: Patients with sepsis in the intensive care unit (ICU) often experience rapid muscle loss. The urea-to-creatinine ratio (UCR) is thought to reflect muscle breakdown (creatinine) and catabolism (urea) and is commonly used to assess nutritional and metabolic status. This study aimed to investigate whether changes in UCR (ΔUCR) can predict the development of rapid muscle loss in patients with sepsis.
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