AI Article Synopsis
- * Highlighted the roles of specific proteins, FSTL3 and ADAMTS13, in causing myocardial stress and microvascular issues in COVID-19.
- * Validated findings through a larger patient cohort and an animal model, offering potential new targets for therapy in cardiovascular issues related to COVID-19.
Article Abstract
To gain insights into the mechanisms driving cardiovascular complications in COVID-19, we performed a case-control plasma proteomics study in COVID-19 patients. Our results identify the senescence-associated secretory phenotype, a marker of biological aging, as the dominant process associated with disease severity and cardiac involvement. FSTL3, an indicator of senescence-promoting Activin/TGFβ signaling, and ADAMTS13, the von Willebrand Factor-cleaving protease whose loss-of-function causes microvascular thrombosis, were among the proteins most strongly associated with myocardial stress and injury. Findings were validated in a larger COVID-19 patient cohort and the hamster COVID-19 model, providing new insights into the pathophysiology of COVID-19 cardiovascular complications with therapeutic implications.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9067411 | PMC |
| http://dx.doi.org/10.1016/j.jacbts.2022.01.013 | DOI Listing |
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