Phytopathogenic fungi have become a serious threat to the quality of agricultural products, food security and human health globally, necessitating the need to discover new antifungal agents with chemical scaffolds and high efficiency. A series of 8-hydroxyquinoline derivatives were designed and synthesized, and their antifungal activity was evaluated against five phytopathogenic fungi. assays revealed that most of the tested compounds remarkably impacted the five target fungi and their inhibitory activities were better than that of the positive control azoxystrobin. Compound 2, in particular, exhibited the highest potency among all the tested compounds, with an EC of 0.0021, 0.0016, 0.0124, 0.0059 and 0.0120 mM respectively against , , , and , followed by compound 5c. The morphological observations of optical microscopy and scanning electron microscopy revealed that compounds 2 and 5c caused mycelial abnormalities of . Futhermore, the results of antifungal activity of compounds 2 and 5c against showed that 5c possessed stronger protective and curative activity than that of 2, and the curative effects of 5c at 40 and 80 μg mL (84.18% and 95.44%) were better than those of azoxystrobin (77.32% and 83.59%). Therefore, compounds 2 and 5c are expected to be novel lead structures for the development of new fungicides.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072087 | PMC |
| http://dx.doi.org/10.1039/c9ra05712a | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
8-Hydroxyquinoline derivative as a promising antifungal agent to combat ocular fungal infections.
J Med Microbiol
January 2025
Programa de Ps-Graduao em Cincias Farmacuticas, Faculdade de Farmcia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Ocular fungal infections are pathologies of slow progression, occurring mainly in the cornea, but can also affect the entire structure of the eyeball. The main aetiological agents are species of the genera and . Both diagnosis and treatment require speed and effectiveness.
View Article and Find Full Text PDFCrystal structures and photophysical properties of mono- and dinuclear Zn complexes flanked by tri-ethyl-ammonium.
Acta Crystallogr E Crystallogr Commun
October 2024
Department of Chemistry, KU Leuven, Biomolecular Architecture, Celestijnenlaan 200F, Leuven (Heverlee), B-3001, Belgium.
Two new zinc(II) complexes, tri-ethyl-ammonium di-chlorido-[2-(4-nitro-phen-yl)-4-phenyl-quinolin-8-olato]zinc(II), (CHN){Zn(CHNO)Cl] (), and bis-(tri-ethyl-ammonium) {2,2'-[1,4-phenyl-enebis(nitrilo-methyl-idyne)]diphenolato}bis-[di-chlorido-zinc(II)], (CHN)[Zn(CHNO)Cl] (), were synthesized and their structures were determined using ESI-MS spectrometry, H NMR spectroscopy, and single-crystal X-ray diffraction. The results showed that the ligands 2-(4-nitro-phen-yl)-4-phenyl-quinolin-8-ol () and ,'-bis-(2-hy-droxy-benzyl-idene)benzene-1,4-di-amine () were deprotonated by tri-ethyl-amine, forming the counter-ion EtNH, which inter-acts an N-H⋯O hydrogen bond with the ligand. The Zn atoms have a distorted trigonal-pyramidal () and distorted tetra-hedral () geometries with a coord-ination number of four, coordinating with the ligands N and O atoms.
View Article and Find Full Text PDFMultifunctional hydroxyquinoline-derived turn-on fluorescent probe for Alzheimer's disease detection and therapy.
J Mater Chem B
December 2024
Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781039, Assam, India.
Understanding molecular motifs that can interfere with amyloid fibrillation through non-covalent interactions is essential for addressing abnormal protein aggregation and associated human diseases. The pursuit of efficient diagnostic and treatment approaches for Alzheimer's disease (AD) has resulted in the development of M8HQ, a multifaceted small molecule turn-on probe derived from 8-hydroxyquinoline with versatile capabilities. M8HQ shows a strong affinity for amyloid beta (Aβ) fibrils, and its ability to target lysosomes enhances therapeutic precision by localizing within these organelles.
View Article and Find Full Text PDFBiotin functionalization of 8-hydroxyquinoline anticancer organometallics: low toxicity but potent activity.
Dalton Trans
December 2024
School of Chemical Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
[M(arene)(HQ)Cl] complexes (M = Ru/Os/Rh/Ir; HQ = 8-hydroxyquinoline) have shown promise as anticancer agents. To assess the effect of conjugating biotin (vitamin B7) to such compounds and improve their tumor-targeting ability through interaction with the sodium-dependent multivitamin transporter (SMVT), the chlorido co-ligand was exchanged with biotinylated 6-aminoindazole. The complexes were characterized by NMR spectroscopy and mass spectrometry, and purity was determined by elemental analysis.
View Article and Find Full Text PDFOrganometallic Half-Sandwich Complexes of 8-Hydroxyquinoline-Derived Mannich Bases with Enhanced Solubility: Targeting Multidrug Resistant Cancer.
Inorg Chem
December 2024
MTA-SZTE Lendület Functional Metal Complexes Research Group, University of Szeged, Dóm tér 7-8, Szeged H-6720 , Hungary.
Drug resistance is a major obstacle in cancer treatment. Herein, four novel organometallic complexes, with the general formula [Ru(η--cymene)(HL)Cl]Cl and [Rh(η-CMe)(HL)Cl]Cl, were developed to target multidrug-resistant (MDR) cancer cells, where HL denotes 8-hydroxyquinoline-derived Mannich bases (HQCl-pyr and HQCl-pip). The aim of the complexation was to obtain compounds with improved drug-like properties.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!