Twelve undescribed sesquiterpenoids, fomitopins A-L (1-12), were isolated bioassay-guided purification from the bracket fungus (Sw.) P. Karst, and this fungus have been reported to exhibit anti-microbial and anti-inflammatory activities. The structures of 1-12 were elucidated by spectroscopic and spectrometric analyses and their absolute configurations were further confirmed by ECD simulations. Ten isolated compounds were evaluated for their anti-inflammatory potential and compound 11 exhibited the most significant inhibition of superoxide anion generation and elastase release with IC values of 0.81 ± 0.15 and 0.74 ± 0.12 μM. These newly purified sesquiterpenoids could be potential candidates for further anti-inflammatory studies.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9073629PMC
http://dx.doi.org/10.1039/c9ra05899kDOI Listing

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