Osteoporosis is an age-related systemic bone disease that places a heavy burden on patients and society. In this study, we aimed to investigate the effects of naringin (NAR) on the osteogenic differentiation of human adipose-derived stromal cells (ADSCs). The results demonstrated that NAR pretreatment effectively abated HO-induced cell death and ROS accumulation in ADSCs undergoing osteogenic differentiation (ADSCs-OD). In addition, we also observed that the impaired extracellular matrix mineralization and ALP activity in HO-stimulated ADSCs-OD were notably rescued by NAR pretreatment. Moreover, the effects of HO exposure on Wnt/-catenin signaling in ADSCs-OD were largely reversed by NAR pretreatment. Collectively, our findings indicated that NAR could protect ADSCs-OD against HO-inhibited osteogenic differentiation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9076301 | PMC |
| http://dx.doi.org/10.1155/2022/3126094 | DOI Listing |
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