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Performance comparison of high-speed photoacoustic microscopy: opto-ultrasound combiner versus ring-shaped ultrasound transducer. | LitMetric

Performance comparison of high-speed photoacoustic microscopy: opto-ultrasound combiner versus ring-shaped ultrasound transducer.

Biomed Eng Lett

Departments of Electrical Engineering, Convergence IT Engineering, Mechanical Engineering, and Interdisciplinary Bioscience and Bioengineering, Medical Device Innovation Center, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang, Gyeongbuk 37673 Republic of Korea.

Published: May 2022

AI Article Synopsis

  • - Photoacoustic microscopy (PAM) using a 532 nm pulse laser helps visualize microvascular structures in living organisms, but traditional opto-ultrasound combiners (OUC) face issues with acoustic impedance that limit sensitivity.
  • - The study compares the performance of OUC with a ring-shaped ultrasound transducer (RUT), finding that the RUT provides significantly higher signal-to-noise ratios (SNR) across various tests, indicating better performance.
  • - The RUT-based system not only enhances sensitivity and image detail but also enables rapid imaging of small mouse body parts, suggesting it could greatly improve future fast-PAM technology.

Article Abstract

Photoacoustic microscopy (PAM) embedded with a 532 nm pulse laser is widely used to visualize the microvascular structures in both small animals and humans in vivo. An opto-ultrasound combiner (OUC) is often utilized in high-speed PAM to confocally align the optical and acoustic beams to improve the system's sensitivity. However, acoustic impedance mismatch in the OUC results in little improvement in the sensitivity. Alternatively, a ring-shaped ultrasound transducer (RUT) can also accomplish the confocal configuration. Here, we compare the performance of OUC and RUT modules through ultrasound pulse-echo tests and PA imaging experiments. The signal-to-noise ratios (SNRs) of the RUT-based system were 15 dB, 12 dB, and 7 dB higher when compared to the OUC-based system for ultrasound pulse-echo test, PA phantom imaging test, and PA in-vivo imaging test, respectively. In addition, the RUT-based system could image the microvascular structures of small parts of a mouse body in a few seconds with minimal loss in SNR. Thus, with increased sensitivity, improved image details, and fast image acquisition, we believe the RUT-based systems could play a significant role in the design of future fast-PAM systems.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9046515PMC
http://dx.doi.org/10.1007/s13534-022-00218-yDOI Listing

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