A novel trifunctional imaging probe containing a chelator of radiometal for PET, a NIR heptamethine cyanine dye, and a bioconjugatable handle, has been grafted onto AGuIX® nanoparticles a Michael addition reaction. The resulting functionalized nanoparticles have been fully characterized, radiolabelled with Cu, and evaluated in a mice TSA tumor model using multimodal (PET/MRI/optical) imaging.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9073358 | PMC |
| http://dx.doi.org/10.1039/c9ra00365g | DOI Listing |
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