AI Article Synopsis
- Gonadotropins can successfully induce sperm production in men with congenital combined pituitary hormone deficiency (CCPHD), but the effect of adding recombinant human growth hormone (rhGH) has been less studied.
- In a study involving 60 male patients, those treated with both rhGH and gonadotropins experienced a significantly higher rate of spermatogenesis (96.77%) and a faster onset of sperm production compared to those receiving gonadotropins alone (62.07%).
- The findings suggest that rhGH not only improves sperm production but also increases testosterone levels, indicating that combining rhGH with gonadotropins could be a beneficial treatment strategy for CCPHD patients.
Article Abstract
Background: Gonadotropins are effective in inducing spermatogenesis in patients with congenital combined pituitary hormone deficiency (CCPHD). Data on recombinant human growth hormone(rhGH) adjuvant treatment to improve gonadotropin-induced spermatogenesis are limited.
Design And Setting: This retrospective study included 60 male patients with CCPHD on a relatively large case series in a single center from mainland China. Twenty-nine patients who received gonadotropin therapy alone were defined as the Gn group, while 31 patients treated with a combination of rhGH and gonadotropins were defined as GH/Gn group.
Results: Spermatogenesis rate was 96.77% (30/31) and 62.07% (18/29) in the GH/Gn and Gn group, respectively (P < 0.001). The time for initial sperm appearance in the GH/Gn group was shorter than in the Gn group (14 versus 23 months, P < 0.001). A higher level of serum testosterone was achieved in the GH/Gn group than in the Gn group (4.79 versus 3.38 ng/mL, P = 0.026). After adjustment for potential confounders, rhGH supplementation was an independent beneficial factor on spermatogenesis (HR = 2.294, 95% CI: 1.143-4.604, P = 0.019).
Conclusions: rhGH induces earlier spermatogenesis in patients with CCPHD, which encourages the co-treatment with rhGH and gonadotropins in CCPHD patients.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9074387 | PMC |
| http://dx.doi.org/10.3389/fendo.2022.868047 | DOI Listing |
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