We constructed two fluorescent probes for monitoring HO in the mitochondria and lysosomes. Fluorescence imaging reveals that mitochondrial HO mediates reduced GCase activity in lysosomes in the brains of mice with depression. This work provides a powerful tool for understanding the pathogenesis of depression.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/d2cc00431c | DOI Listing |
Publication Analysis
Top Keywords
fluorescence imaging
8
imaging reveals
8
reveals mitochondrial
8
mitochondrial mediates
8
mediates lysosomal
4
lysosomal dysfunction
4
dysfunction depression
4
depression constructed
4
constructed fluorescent
4
fluorescent probes
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!