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Regulation of Siglec-7-mediated varicella-zoster virus infection of primary monocytes by cis-ligands. | LitMetric

Regulation of Siglec-7-mediated varicella-zoster virus infection of primary monocytes by cis-ligands.

Biochem Biophys Res Commun

Department of Immunochemistry, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka, 565-0081, Japan; WPI Immunology Frontier Research Center, Osaka University, 3-1 Yamadaoka, Suita, Osaka, 565-0081, Japan; Center for Infectious Disease Education and Research, Osaka University, Osaka, 565-0871, Japan. Electronic address:

Published: July 2022

AI Article Synopsis

  • Varicella-zoster virus (VZV) initiates infection by targeting hematopoietic cells, which help spread the virus throughout the body.
  • Siglec family molecules, particularly Siglec-4 and Siglec-7, are involved in the infection process by interacting with the virus's glycoprotein B (gB).
  • Siglec-7 is crucial for VZV's infection of human primary monocytes, and treatments that alter sialic acid levels on these cells can significantly increase VZV binding and infection rates.

Article Abstract

Varicella-zoster virus (VZV) first infects hematopoietic cells, with the infected cells then acting to distribute the virus throughout the body. Sialic acid-binding immunoglobulin-like lectin (Siglec) family molecules recognize sialic acid-containing molecules on the same cell surface, called cis-ligands, or molecules on other cells or soluble agents, called trans-ligands. Among the Siglec family molecules, Siglec-4 and Siglec-7 mediate VZV infection through association with glycoprotein B (gB). As Siglec-7, but not Siglec-4, is expressed on hematopoietic cells such as monocytes, the regulatory mechanism by which Siglec-7 associates with gB is important to our understanding of VZV infection of blood cells. Here, we found that Siglec-7 is required for VZV to infect human primary monocytes. Furthermore, treatment of primary monocytes with sialidase enhanced both VZV gB binding to monocytes and VZV infectivity. Calcium influx in primary monocytes decreased the expression of Siglec-7 cis-ligands and increased VZV infectivity. These results demonstrate that the Siglec-7 cis-ligands present on primary monocytes play an important role in VZV infection through regulation of the interaction between gB and Siglec-7.

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Source
http://dx.doi.org/10.1016/j.bbrc.2022.04.111DOI Listing

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