AI Article Synopsis
- Anacardic acid (AA) is a natural phenolic compound found in various plants, known for its diverse biological activities.
- AA has been shown to significantly reduce symptoms in a mouse model of multiple sclerosis (EAE) by decreasing inflammatory cell infiltration in the central nervous system and preserving the myelin integrity of spinal cord white matter.
- The study also revealed that AA inhibits the activation of dendritic cells (DCs), blocks T cell polarization, and suppresses NF-κB phosphorylation in DCs, suggesting its potential as an anti-inflammatory treatment for autoimmune diseases.
Article Abstract
Anacardic acid (AA) is a phenolic acid extract found in a number of plants, crops, and fruits. It exhibits a wide range of biological activities. This study displayed that AA effectively alleviated EAE, a classical mouse model of multiple sclerosis. AA administered to the EAE greatly decreased inflammatory cell infiltration to the CNS and protected the myelin integrity in the white matter of the spinal cord. AA could block lipopolysaccharide-induced DC activation. inhibited the polarization of 2D2 mice-derived T cells by inhibiting the DCs activity. Immunoblot results indicated that the phosphorylation of NF-κB is significantly suppressed in AA-treated DCs. This work displayed that AA possessed a potential anti-inflammatory therapeutic effect for the treatment of autoimmune disease.
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| http://dx.doi.org/10.1016/j.bbrc.2022.04.115 | DOI Listing |
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