AI Article Synopsis
- Cardiomyocytes are specialized heart muscle cells that have a limited ability to regenerate, leading to challenges in recovering from heart disease and injury.
- Recent research suggests that stimulating the proliferation of existing cardiomyocytes is vital for heart renewal, particularly by inhibiting the Hippo signaling pathway.
- This review explores how the Hippo pathway influences heart regeneration through both cell-specific and broader cellular interactions, and highlights successful studies in larger animal models that support targeting this pathway as a potential treatment for heart disease.
Article Abstract
Cardiomyocytes are differentiated heart muscle cells with minimal self-renewal ability. Thus, loss of cardiomyocytes from cardiovascular disease and injury cannot be effectively replenished. Recent studies in animal models have indicated that induction of endogenous cardiomyocyte proliferation is essential for cardiac renewal and that inhibiting the Hippo signaling pathway can stimulate cardiomyocyte proliferation and heart regeneration. Increasing evidence has suggested that cardiomyocyte proliferation requires a permissive microenvironment that consists of multiple cell types. In this review, we summarize recent studies that highlight how the Hippo pathway regulates heart regeneration through cell-autonomous and non-cell-autonomous mechanisms. We also discuss recent translational studies in large animal models that demonstrate the therapeutic potential of targeting the Hippo pathway in the treatment of heart disease.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9713691 | PMC |
| http://dx.doi.org/10.1016/j.yjmcc.2022.04.018 | DOI Listing |
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